ChatGPT 에게 전문 지식에 대해 물어볼 때 조심해야 할 점: 가짜 정보를 마치 사실인 것처럼 이야기한다는 점이다.
우선, synaptic pruning이라는 신경생물학 이론에 대해 설명하는 아래 글에 나오는 Dr. Beatrice Golgi는 현실에 존재하지 않는 연구자다. 그리고 신경계에서의 'synaptic pruning (시냅스 가지치기)' 이론은 1990년대에 Dr. Golgi가 아니라 1979년 Peter Huttenlocher에 의해 최초로 나온 이론이다.
(논문: https://doi.org/10.1016/0006-8993(79)90349-4 / 리뷰: https://doi.org/10.1073/pnas.2010281117)
ChatGPT: "The concept of synaptic pruning in humans was first introduced in the 1990s by a group of researchers led by Dr. Beatrice Golgi. In a series of seminal papers, Golgi and her colleagues proposed that the human brain undergoes a process of synapse elimination during development, which leads to the refinement and specialization of neural circuits. This process, which they referred to as "synaptic pruning," was suggested to play an important role in the maturation and optimization of the nervous system."
"Can you provide references for the brain-targeting antibodies causing increase of the target proteins in blood level?"
• A study by El-Agnaf et al. (2006) looked at the effects of an anti-amyloid beta antibody in a mouse model of Alzheimer's disease. They found that treatment with the antibody led to a significant increase in blood levels of amyloid beta.
• A study by Boutajangout et al. (2016) examined the effects of an anti-alpha-synuclein antibody in a mouse model of Parkinson's disease. They found that treatment with the antibody led to a significant increase in blood levels of alpha-synuclein.
• A study by Kim et al. (2018) investigated the effects of an anti-Tau antibody in a mouse model of tauopathy. They found that treatment with the antibody led to a significant increase in blood levels of Tau.
References:
• El-Agnaf OM, Salem SA, Ali MA, et al. Antibodies to beta-amyloid peptide reduce beta-amyloid peptide levels in brain and blood of transgenic mice. J Neurosci. 2006;26(35):8989–8995. doi:10.1523/JNEUROSCI.1591-06.2006
• Boutajangout A, Bousset L, Melki R. Alpha-synuclein antibodies increase blood alpha-synuclein levels in a mouse model of Parkinson disease. Neurobiol Dis. 2016;93:139–145. doi:10.1016/j.nbd.2016.04.006
• Kim J, Lee J, Kim J, et al. Passive immunization with anti-tau antibody reduces tau accumulation and neurodegeneration in a mouse model of tauopathy. Sci Rep. 2018;8(1):10261. Published 2018 Jul 20. doi:10.1038/s41598-018-28489-y
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